Berman BM, Langevin HM, Witt CM, Dubner R. Acupuncture for chronic low back pain. N Engl J Med. 2010;363:454–61.
Binch ALA, Fitzgerald JC, Growney EA, Barry F. Cell-based strategies for IVD repair: clinical progress and translational obstacles. Nat Rev Rheumatol. 2021;17:158–75.
Humzah MD, Soames RW. Human intervertebral disc: structure and function. Anat Rec. 1988;220:337–56.
Lyu FJ, Cheung KM, Zheng Z, Wang H, Sakai D, Leung VY. IVD progenitor cells: a new horizon for understanding disc homeostasis and repair. Nat Rev Rheumatol. 2019;15:102–12.
Dou Y, Sun X, Ma X, Zhao X, Yang Q. Intervertebral disk degeneration: the microenvironment and tissue engineering strategies. Front Bioeng Biotechnol. 2021;9: 592118.
Shedid D, Ugokwe KT, Benzel EC. Lumbar total disc replacement compared with spinal fusion: treatment choice and evaluation of outcome. Nat Clin Pract Neurol. 2005;1:4–5.
Hudson KD, Alimi M, Grunert P, Härtl R, Bonassar LJ. Recent advances in biological therapies for disc degeneration: tissue engineering of the annulus fibrosus, nucleus pulposus and whole intervertebral discs. Curr Opin Biotechnol. 2013;24:872–9.
Sakai D, Mochida J, Iwashina T, Hiyama A, Omi H, Imai M, et al. Regenerative effects of transplanting mesenchymal stem cells embedded in atelocollagen to the degenerated intervertebral disc. Biomaterials. 2006;27:335–45.
Sakai D, Mochida J, Yamamoto Y, Nomura T, Okuma M, Nishimura K, et al. Transplantation of mesenchymal stem cells embedded in atelocollagen gel to the intervertebral disc: a potential therapeutic model for disc degeneration. Biomaterials. 2003;24:3531–41.
Luo D, Saltzman WM. Synthetic DNA delivery systems. Nat Biotechnol. 2000;18:33–7.
Kumar S, Anders HJ. Glomerular disease: limiting autoimmune tissue injury: ROS and the inflammasome. Nat Rev Nephrol. 2014;10:545.
Zhou J, Liu W, Zhao X, Xian Y, Wu W, Zhang X, et al. Natural melanin/alginate hydrogels achieve cardiac repair through ros scavenging and macrophage polarization. Adv Sci (Weinh). 2021;8: e2100505.
Yim D, Lee DE, So Y, Choi C, Son W, Jang K, et al. Sustainable nanosheet antioxidants for sepsis therapy via scavenging intracellular reactive oxygen and nitrogen species. ACS Nano. 2020;14:10324–36.
Liu Y, Cheng Y, Zhang H, Zhou M, Wei H. Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy. Sci Adv. 2020. https://doi.org/10.1126/sciadv.abb2695.
Yu C, Li D, Wang C, Xia K, Wang J, Zhou X, et al. Injectable kartogenin and apocynin loaded micelle enhances the alleviation of intervertebral disc degeneration by adipose-derived stem cell. Bioact Mater. 2021;6:3568–79.
Srivastava A, Isa IL, Rooney P, Pandit A. Bioengineered three-dimensional diseased intervertebral disc model revealed inflammatory crosstalk. Biomaterials. 2017;123:127–41.
Mohd Isa IL, Abbah SA, Kilcoyne M, Sakai D, Dockery P, Finn DP, et al. Implantation of hyaluronic acid hydrogel prevents the pain phenotype in a rat model of intervertebral disc injury. Sci Adv. 2018;4:eaaq0597.
Song Y, Li S, Geng W, Luo R, Liu W, Tu J, et al. Sirtuin 3-dependent mitochondrial redox homeostasis protects against AGEs-induced intervertebral disc degeneration. Redox Biol. 2018;19:339–53.
Feng C, Yang M, Lan M, Liu C, Zhang Y, Huang B, et al. ROS: crucial intermediators in the pathogenesis of intervertebral disc degeneration. Oxid Med Cell Longev. 2017;2017:5601593.
Krupkova O, Handa J, Hlavna M, Klasen J, Ospelt C, Ferguson SJ, et al. The natural polyphenol epigallocatechin gallate protects intervertebral disc cells from oxidative stress. Oxid Med Cell Longev. 2016;2016:7031397.
Li X, Phillips FM, An HS, Ellman M, Thonar EJ, Wu W, et al. The action of resveratrol, a phytoestrogen found in grapes, on the intervertebral disc. Spine. 2008;33:2586–95.
Cheng YH, Yang SH, Lin FH. Thermosensitive chitosan-gelatin-glycerol phosphate hydrogel as a controlled release system of ferulic acid for nucleus pulposus regeneration. Biomaterials. 2011;32:6953–61.
Wei Z, Hu S, Yin JJ, He W, Wei L, Ma M, et al. Prussian blue nanoparticles as multi-enzyme mimetics and ros scavengers. J Am Chem Soc. 2016;138:5860–5.
Jing L, Liang X, Deng Z, Feng S, Li X, Huang M, et al. Prussian blue coated gold nanoparticles for simultaneous photoacoustic/CT bimodal imaging and photothermal ablation of cancer. Biomaterials. 2014;35:5814–21.
Wang T, Lei QL, Wang M, Deng G, Yang L, Liu X, et al. mechanical tolerance of cascade bioreactions via adaptive curvature engineering for epidermal bioelectronics. Adv Mater. 2020;32: e2000991.
Cai X, Gao W, Ma M, Wu M, Zhang L, Zheng Y, et al. A prussian blue-based core-shell hollow-structured mesoporous nanoparticle as a smart theranostic agent with ultrahigh ph-responsive longitudinal relaxivity. Adv Mater. 2015;27:6382–9.
Zhu D, Zheng Z, Luo G, Suo M, Tang BZ. Single injection and multiple treatments: an injectable nanozyme hydrogel as AIEgen reservoir and release controller for efficient tumor therapy. Nano Today. 2021;37: 101091.
Liu J, Li X, Rykov AI, Fan Q, Xu W, Cong W, et al. Zinc-modulated Fe-Co Prussian blue analogues with well-controlled morphologies for the efficient sorption of cesium. J Mater Chem A. 2017;5:3284–92.
Feng L, Dou C, Xia Y, Li B, Zhao M, Yu P, et al. Neutrophil-like cell-membrane-coated nanozyme therapy for ischemic brain damage and long-term neurological functional recovery. ACS Nano. 2021;15:2263–80.
Hou W, Ye C, Chen M, Gao W, Xie X, Wu J, et al. Excavating bioactivities of nanozyme to remodel microenvironment for protecting chondrocytes and delaying osteoarthritis. Bioact Mater. 2021;6:2439–51.
Xie X, Zhao J, Gao W, Chen J, Hu B, Cai X, et al. Prussian blue nanozyme-mediated nanoscavenger ameliorates acute pancreatitis via inhibiting TLRs/NF-κB signaling pathway. Theranostics. 2021;11:3213–28.
Altay C, Fagerhol MK, Erdogan N, Say B. Additional evidence for a deleted gene for serum α1-antitrypsin. N Engl J Med. 1973;289:754.
Shikinami Y, Kotani Y, Cunningham B, Abumi K, Kaneda K. A biomimetic artificial disc with improved mechanical properties compared to biological intervertebral discs. Adv Funct Mater. 2010;14:1039–46.
Borrelli C, Buckley CT. Injectable disc-derived ecm hydrogel functionalised with chondroitin sulfate for intervertebral disc regeneration. Acta Biomater. 2020;117:142–55.
Sloan SR, Wipplinger C, Kirnaz S, Navarro-Ramirez R, Schmidt F, McCloskey D, et al. Combined nucleus pulposus augmentation and annulus fibrosus repair prevents acute intervertebral disc degeneration after discectomy. Sci Transl Med. 2020;12:eaay2380.
Wang Y, Li L, Ma Y, Tang Y, Zhao Y, Li Z, et al. Multifunctional supramolecular hydrogel for prevention of epidural adhesion after laminectomy. ACS Nano. 2020;14:8202–19.
Rawlings CE, Wilkins RH, Gallis HA, Goldner JL, Francis R. Postoperative intervertebral disc space infection. Neurosurgery. 1983;13:371–6.
Afewerki S, Wang X, Ruiz-Esparza GU, Tai CW, Kong X, Zhou S, et al. Combined catalysis for engineering bioinspired, lignin-based, long-lasting, adhesive, self-mending. Antimicrobial Hydrogels ACS Nano. 2020;14:17004–17.
Zhu C, Fu Y, Liu C, Liu Y, Hu L, Liu J, et al. Carbon dots as fillers inducing healing/self-healing and anticorrosion properties in polymers. Adv Mater. 2017;29:1701399.
Mao X, Cheng R, Zhang H, Bae J, Cheng L, Zhang L, et al. Self-healing and injectable hydrogel for matching skin flap regeneration. Adv Sci. 2019;6:1801555.
Zhou L, Dai C, Fan L, Jiang Y, Tan G. injectable self-healing natural biopolymer〣ased hydrogel adhesive with thermoresponsive reversible adhesion for minimally invasive surgery. Adv Funct Mater. 2021;31:2007457.
Chu CK, Joseph AJ, Limjoco MD, Yang J, Bose S, Thapa LS, et al. Chemical tuning of fibers drawn from extensible hyaluronic acid networks. J Am Chem Soc. 2020;142:19715–21.
Feng Z, Su Q, Zhang C, Huang P, Song H, Dong A, et al. Bioinspired nanofibrous glycopeptide hydrogel dressing for accelerating wound healing: a cytokine-free, m2-type macrophage polarization approach. Adv Funct Mater. 2020;30:2006454.
Tang J, Xi K, Chen H, Wang L, Li D, Xu Y, et al. Flexible osteogenic glue as an all-in-one solution to assist fracture fixation and healing. Adv Funct Mater. 2021;31:2102465.
Liang Y, Li Z, Huang Y, Yu R, Guo B. Dual-dynamic-bond cross-linked antibacterial adhesive hydrogel sealants with on-demand removability for post-wound-closure and infected wound healing. ACS Nano. 2021;15:7078–93.
Chen T, Yao T, Peng H, Whittaker AK, Li Y, Zhu S, et al. An Injectable hydrogel for simultaneous photothermal therapy and photodynamic therapy with ultrahigh efficiency based on carbon dots and modified cellulose nanocrystals. Adv Funct Mater. 2021;31:2106079.
Zhang S, Hou J, Yuan Q, Xin P, Wu J. Arginine derivatives assist dopamine-hyaluronic acid hybrid hydrogels to have enhanced antioxidant activity for wound healing. Chem Eng J. 2019;392: 123775.
Ma X, Hao J, Wu J, Li Y, Cai X, Zheng Y. Prussian blue nanozyme as a pyroptosis inhibitor alleviates neurodegeneration. Adv Mater. 2022;34: e2106723.
Pettignano A, Häring M, Bernardi L, Tanchoux N, Quignard F, Díaz DD. Self-healing alginate-gelatin biohydrogels based on dynamic covalent chemistry: elucidation of key parameters. Mater Chem Front. 2017;1:73–9.
Yang B, Song J, Jiang Y, Li M, Gu Z. Injectable adhesive self-healing multicross-linked double-network hydrogel facilitates full-thickness skin wound healing. ACS Appl Mater Interfaces. 2020;12:57782–97.
Hu B, Gao M, Boakye-Yiadom KO, Ho W, Yu W, Xu X, et al. An intrinsically bioactive hydrogel with on-demand drug release behaviors for diabetic wound healing. Bioact Mater. 2021;6:4592–606.
Coddington JM, Taylor MJ. High field 11B and 13C Nmr investigations of aqueous borate solutions and borate-diol complexes. J Coord Chem. 1989;20:27–38.
Wang L, Deng F, Wang W, Li A, Lu C, Chen H, et al. Construction of injectable self-healing macroporous hydrogels via a template-free method for tissue engineering and drug delivery. ACS Appl Mater Interfaces. 2018;10:36721–32.
Tang X, Wang X, Sun Y, Zhao L, Li D, Zhang J, et al. Magnesium oxide-assisted dual-cross-linking bio-multifunctional hydrogels for wound repair during full-thickness skin injuries. Adv Funct Mater. 2021;31:2105718.
Li J, Yu F, Chen G, Liu J, Li XL, Cheng B, et al. Moist-retaining, self-recoverable, bioadhesive, and transparent in situ forming hydrogels to accelerate wound healing. ACS Appl Mater Interfaces. 2020;12:2023–38.
Wang Z, Zhang Y, Yin Y, Liu J, Li P, Zhao Y, et al. High-strength and injectable supramolecular hydrogel self-assembled by monomeric nucleoside for tooth-extraction wound healing. Adv Mater. 2022;34:2108300.
Ren J, Zhang Y, Zhang J, Gao H, Liu G, Ma R, et al. pH/sugar dual responsive core-cross-linked PIC micelles for enhanced intracellular protein delivery. Biomacromol. 2013;14:3434–43.
Wang N, Zeng Q, Zhang R, Xing D, Zhang T. Eradication of solid tumors by chemodynamic theranostics with H2O2-catalyzed hydroxyl radical burst. Theranostics. 2021;11:2334–48.
Bian J, Cai F, Chen H, Tang Z, Xi K, Tang J, et al. Modulation of local overactive inflammation via injectable hydrogel microspheres. Nano Lett. 2021;21:2690–8.
Tan H, Jin D, Sun J, Song J, Lu Y, Yin M, et al. Enlisting a traditional Chinese Medicine to tune the gelation kinetics of a bioactive tissue adhesive for fast hemostasis or minimally invasive therapy. Bioact Mater. 2021;6:905–17.
Chen W, Ouyang J, Liu H, Chen M, Zeng K, Sheng J, et al. Black phosphorus nanosheet-based drug delivery system for synergistic photodynamic/photothermal/chemotherapy of cancer. Adv Mater. 2017;29:1603864.
Zhao J, Cai X, Gao W, Zhang L, Zou D, Zheng Y, et al. Prussian blue nanozyme with multienzyme activity reduces colitis in mice. ACS Appl Mater Interfaces. 2018;10:26108–17.
Ao X, Wang L, Shao Y, Chen X, Zhang J, Chu J, et al. Development and characterization of a novel bipedal standing mouse model of intervertebral disc and facet joint degeneration. Clin Orthop Relat Res. 2019;477:1492–504.
Keorochana G, Johnson JS, Taghavi C, Liao JC, Lee KB, Yoo JH, et al. The effect of needle size inducing degeneration in the rat caudal disc: evaluation using radiograph, magnetic resonance imaging, histology, and immunohistochemistry. Spine J. 2010;10:1014–23.
Han B, Zhu K, Li FC, Xiao YX, Feng J, Shi ZL, et al. A simple disc degeneration model induced by percutaneous needle puncture in the rat tail. Spine. 2008;33:1925–34.
Gan Y, Li P, Wang L, Mo X, Song L, Xu Y, et al. An interpenetrating network-strengthened and toughened hydrogel that supports cell-based nucleus pulposus regeneration. Biomaterials. 2017;136:12–28.
Zhou T, Yang X, Chen Z, Yang Y, Wang X, Cao X, et al. Prussian blue nanoparticles stabilize sod1 from ubiquitination-proteasome degradation to rescue intervertebral disc degeneration. Adv Sci. 2022;9: e2105466.
Gullbrand SE, Ashinsky BG, Bonnevie ED, Kim DH, Engiles JB, Smith LJ, et al. Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc. Sci Trans Med. 2018;10:0670.