This tutorial evaluation describes the continued effort to transform main-group components of the periodic desk and their mixtures into secure 2D supplies, which is usually referred to as fashionable ‘alchemy’. Idea is efficiently approaching this objective, whereas experimental verification is lagging far behind within the synergistic interaction between principle and experiment. The info collected right here offers a transparent image of the bonding, construction, and mechanical efficiency of the main-group components and their binary compounds. This ranges from group II components, with two valence electrons, to group VI components with six valence electrons, which kind not solely 1D buildings but additionally, owing to their variable oxidation states, low-symmetry 2D networks. Exterior of those predominant teams reviewed right here, predominantly ionic bonding could also be noticed, for instance in group II–VII compounds. Moreover high-symmetry graphene with its shortest and strongest bonds and excellent mechanical properties, low-symmetry 2D buildings reminiscent of varied borophene and tellurene phases with intriguing properties are receiving growing consideration. The excellent dialogue of information additionally contains bonding and construction of few-layer assemblies, as a result of the digital properties, e.g., the band hole, of those heterostructures range with interlayer layer separation and interplay vitality. The out there information permits the identification of basic relationships between bonding, construction, and mechanical stability. This permits the extraction of periodic developments and basic guidelines governing the 2D world, which assist to clear up deviating outcomes and to estimate unknown properties. For instance, the noticed change of the bond size by an element of two alters the cohesive vitality by an element of 4 and the extraordinarily delicate Younger’s modulus and supreme energy by greater than an element of 60. Because the stiffness and energy lower with growing atom measurement on happening the columns of the periodic desk, you will need to search for appropriate allotropes of components and binaries within the higher rows of the periodic desk when mechanical stability and robustness are points. Then again, the heavy compounds are of specific curiosity due to their low-symmetry buildings with unique digital properties.